Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R.
Amino Acids
; 56(1): 25, 2024 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-38512589
ABSTRACT
Nowadays, a healthier and more sustainable lifestyle is the subject of much research. One example is the use of crossover trials to investigate the uptake of proteins, usually from alternatives to animal-based sources, by healthy volunteers. The data analysis is complex and requires many decisions on the part of the scientists involved. Such a process can be streamlined and made more objective and reproducible through bespoke software. This paper describes such a software package, aaresponse , for the R environment, available as open source. It features ample visualization functions, supports consistent curation strategies, and compares amino acid uptake of different protein meals (interventions) through the use of mixed models analysing parameters of interest like the area under the curve (AUC). The defining feature is the use of parametric curves to fit the amino acid levels over time, increasing the robustness of the approach and allowing for more strict quality control strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Aminoácidos
Límite:
Humans
Idioma:
En
Revista:
Amino Acids
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Países Bajos