Impact of changes in Achilles tendon thickening on cardiovascular events in patients with familial hypercholesterolemia.
Am J Prev Cardiol
; 18: 100660, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38590629
ABSTRACT
Background:
Achilles tendon thickening (ATT) can be ameliorated by lowering low-density lipoprotein (LDL) levels in patients with familial hypercholesterolemia (FH). The Japan Atherosclerosis Society (JAS) defines ATT as ≥8.0 mm in males and ≥7.5 mm in females. We aimed to determine the clinical impact of changes in ATT on the development of major adverse cardiovascular events (MACE).Methods:
Patients with clinically diagnosed heterozygous FH (HeFH) (N = 1273; 614 males, 659 females) with ATT data from X-ray were assessed. Patients were divided into four groups patients without ATT from baseline until follow-up (group 1), patients without ATT at baseline but developed ATT at follow-up (group 2), patients with ATT at baseline but regressed at follow-up (group 3), and patients with ATT from baseline until follow-up (group 4). Cox proportional hazard models were used to assess the factors associated with MACE, including cardiovascular death and any coronary events.Results:
On follow-up (median 10.9 years), 142 MACEs were observed, and the median ATT regressed from 7.8 to 7.6 mm. Changes in ATT were significantly associated with the occurrence of MACE in all groups, when compared to group 1 (hazard ratio [HR] 2.73; 95 % confidence interval [CI] 1.33-4.13 [p < 0.001], HR 2.18, 95 % CI 1.08-3.28, [p < 0.001], HR 6.34, 95 % CI 3.10-9.58, [p < 0.001], in groups 2, 3, and 4, respectively).Conclusions:
Assessing ATT has diagnostic value and allows for risk stratification among patients with HeFH.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Am J Prev Cardiol
/
American journal of preventive cardiology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón