Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins.
J Physiol
; 602(8): 1623-1636, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38598430
ABSTRACT
Two-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca2+-permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the Ca2+ mobilizing messenger NAADP, synthetic agonists including approved drugs and physical cues such as voltage and osmotic pressure. Here, we provide an overview of this coordination.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Canales de Calcio
/
Canales de Potencial de Receptor Transitorio
Idioma:
En
Revista:
J Physiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido