No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian randomization study.
Front Public Health
; 12: 1373044, 2024.
Article
en En
| MEDLINE
| ID: mdl-38601492
ABSTRACT
Objectives:
To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout.Methods:
The random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms (SNPs).Results:
There was no causal association between pneumoconiosis and SLE, RA or gout in the European population [OR = 1.01, 95% CI 0.94-1.10, p = 0.74; OR = 1.00, 95% CI 0.999-1.000, p = 0.50; OR = 1.00, 95% CI 1.000-1.001, p = 0.55]. Causal relationships were also not found in pneumoconiosis due to asbestos and other mineral fibers and SLE, RA and gout [OR = 1.01, 95% CI 0.96-1.07, p = 0.66; OR = 1.00, 95% CI 1.00-1.00, p = 0.68; OR = 1.00, 95% CI 1.00-1.00, p = 0.20].Conclusion:
Our study suggests that pneumoconiosis may have no causal relationship with the three inflammatory immune diseases.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumoconiosis
/
Gota
/
Enfermedades del Sistema Inmune
/
Lupus Eritematoso Sistémico
Límite:
Humans
Idioma:
En
Revista:
Front Public Health
Año:
2024
Tipo del documento:
Article
País de afiliación:
China