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Generation of integration-free human induced pluripotent stem cells from a patient with sporadic Parkinson's disease.
Lee, Yukyeong; Jeong, Dahee; Ham, Seokbeom; Son, Jaeseung; Ko, Kinarm.
Afiliación
  • Lee Y; Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.
  • Jeong D; Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.
  • Ham S; Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.
  • Son J; Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.
  • Ko K; Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea; Center for Stem Cell Research, Institute of Advanced Biomedical Science, Konkuk University, Seoul 05029, Republic of Korea. Electronic address: knko@kku.ac.kr.
Stem Cell Res ; 77: 103416, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38615589
ABSTRACT
A human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson's disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, SOX2/KLF4, L-MYC/LIN28). The KKUi002-A iPSCs displayed typical iPSC morphology, expressed pluripotency markers, differentiated into derivatives of three germ layers, and had a normal karyotype. These PD-derived iPSCs can be used to understand the mechanism underlying PD pathogenesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Células Madre Pluripotentes Inducidas / Factor 4 Similar a Kruppel Límite: Humans / Male / Middle aged Idioma: En Revista: Stem Cell Res Año: 2024 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Células Madre Pluripotentes Inducidas / Factor 4 Similar a Kruppel Límite: Humans / Male / Middle aged Idioma: En Revista: Stem Cell Res Año: 2024 Tipo del documento: Article