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Epithelial cell states associated with kidney and allograft injury.
Hinze, Christian; Lovric, Svjetlana; Halloran, Philip F; Barasch, Jonathan; Schmidt-Ott, Kai M.
Afiliación
  • Hinze C; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
  • Lovric S; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
  • Halloran PF; Alberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada.
  • Barasch J; Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Alberta, Canada.
  • Schmidt-Ott KM; Division of Nephrology, Columbia University, New York City, NY, USA.
Nat Rev Nephrol ; 20(7): 447-459, 2024 07.
Article en En | MEDLINE | ID: mdl-38632381
ABSTRACT
The kidney epithelium, with its intricate arrangement of highly specialized cell types, constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of functional nephrons and a subsequent decline in kidney function. In kidney transplantation, epithelial injury signatures observed during post-transplantation surveillance are strong predictors of adverse kidney allograft outcomes. However, epithelial injury is currently neither monitored clinically nor addressed therapeutically after kidney transplantation. Several factors can contribute to allograft epithelial injury, including allograft rejection, drug toxicity, recurrent infections and postrenal obstruction. The injury mechanisms that underlie allograft injury overlap partially with those associated with acute kidney injury (AKI) and chronic kidney disease (CKD) in the native kidney. Studies using advanced transcriptomic analyses of single cells from kidney or urine have identified a role for kidney injury-induced epithelial cell states in exacerbating and sustaining damage in AKI and CKD. These epithelial cell states and their associated expression signatures are also observed in transplanted kidney allografts, suggesting that the identification and characterization of transcriptomic epithelial cell states in kidney allografts may have potential clinical implications for diagnosis and therapy.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Riñón / Células Epiteliales / Lesión Renal Aguda / Aloinjertos Límite: Humans Idioma: En Revista: Nat Rev Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Riñón / Células Epiteliales / Lesión Renal Aguda / Aloinjertos Límite: Humans Idioma: En Revista: Nat Rev Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania