Biosynthesis and Metabolism of ApoB-Containing Lipoproteins.
Annu Rev Nutr
; 44(1): 179-204, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38635875
ABSTRACT
Recent advances in human genetics, together with a substantial body of epidemiological, preclinical and clinical trial evidence, strongly support a causal relationship between triglyceride-rich lipoproteins (TRLs) and atherosclerotic cardiovascular disease. Consequently, the secretion and metabolism of TRLs have a significant impact on cardiovascular health. This knowledge underscores the importance of understanding the molecular mechanisms and regulation of very-low-density lipoprotein (VLDL) and chylomicron biogenesis. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL, leading to many ground-breaking molecular insights. Furthermore, the identification of molecular control mechanisms related to triglyceride metabolism has greatly advanced our understanding of the complex metabolism of TRLs. In this review, we explore recent advances in the assembly, secretion, and metabolism of TRLs. We also discuss available treatment strategies for hypertriglyceridemia.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Triglicéridos
/
Lipoproteínas VLDL
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Nutr
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suecia