Reduction of the hepatic radioactivity levels of [<sup>111</sup>In]In-DOTA-labeled antibodies via cleavage of a linkage metabolized in lysosomes.

Suzuki, Hiroyuki; Matsukawa, Masato; Madokoro, Rikako; Terasaka, Yui; Kannaka, Kento; Uehara, Tomoya

Reduction of the hepatic radioactivity levels of [¹¹¹In]In-DOTA-labeled antibodies via cleavage of a linkage metabolized in lysosomes.

Suzuki, Hiroyuki; Matsukawa, Masato; Madokoro, Rikako; Terasaka, Yui; Kannaka, Kento; Uehara, Tomoya.

Afiliación

Suzuki H; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: h.suzuki@chiba-u.jp.
Matsukawa M; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Madokoro R; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Terasaka Y; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Kannaka K; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Uehara T; Laboratory of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: tuehara@chiba-u.jp.

Nucl Med Biol ; 132-133: 108910, 2024.

Article en En | MEDLINE | ID: mdl-38636351

Asunto(s)

Hígado; Lisosomas; Animales; Ratones; Hígado/metabolismo; Hígado/diagnóstico por imagen; Lisosomas/metabolismo; Marcaje Isotópico; Distribución Tisular; Radioisótopos de Indio; Línea Celular Tumoral; Humanos; Compuestos Heterocíclicos con 1 Anillo/química; Anticuerpos; Complejos de Coordinación

Palabras clave

Cleavable linkage; DOTA; Immuno-SPECT; Indium-111; Radiometabolite

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hígado / Lisosomas Límite: Animals / Humans Idioma: En Revista: Nucl Med Biol Asunto de la revista: BIOLOGIA / MEDICINA NUCLEAR Año: 2024 Tipo del documento: Article

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