Triumphs and Challenges of Natural Product Discovery in the Postgenomic Era.
Annu Rev Biochem
; 93(1): 411-445, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38639989
ABSTRACT
Natural products have played significant roles as medicine and food throughout human history. Here, we first provide a brief historical overview of natural products, their classification and biosynthetic origins, and the microbiological and genetic methods used for their discovery. We also describe and discuss the technologies that revolutionized the field, which transitioned from classic genetics to genome-centric discovery approximately two decades ago. We then highlight the most recent advancements and approaches in the current postgenomic era, in which genome mining is a standard operation and high-throughput analytical methods allow parallel discovery of genes and molecules at an unprecedented pace. Finally, we discuss the new challenges faced by the field of natural products and the future of systematic heterologous expression and strain-independent discovery, which promises to deliver more molecules in vials than ever before.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Genómica
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2024
Tipo del documento:
Article