The interplay between hippo signaling and mitochondrial metabolism: Implications for cellular homeostasis and disease.
Mitochondrion
; 76: 101885, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38643865
ABSTRACT
Mitochondria are the membrane-bound organelles producing energy for cellular metabolic processes. They orchestrate diverse cell signaling cascades regulating cellular homeostasis. This functional versatility may be attributed to their ability to regulate mitochondrial dynamics, biogenesis, and apoptosis. The Hippo pathway, a conserved signaling pathway, regulates various cellular processes, including mitochondrial functions. Through its effectors YAP and TAZ, the Hippo pathway regulates transcription factors and creates a seriatim process that mediates cellular metabolism, mitochondrial dynamics, and survival. Mitochondrial dynamics also potentially regulates Hippo signaling activation, indicating a bidirectional relationship between the two. This review outlines the interplay between the Hippo signaling components and the multifaceted role of mitochondria in cellular homeostasis under physiological and pathological conditions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vía de Señalización Hippo
/
Homeostasis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mitochondrion
Año:
2024
Tipo del documento:
Article
País de afiliación:
India