Astrocytes at the intersection of ageing, obesity, and neurodegeneration.
Clin Sci (Lond)
; 138(8): 515-536, 2024 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-38652065
ABSTRACT
Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in CNS physiology and pathophysiology has only grown. Astrocytes, a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration, with a focus on the inflammatory responses and mitochondrial function, and will address therapeutic outlooks.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Astrocitos
/
Enfermedades Neurodegenerativas
/
Obesidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Sci (Lond)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido