Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6-Item Score.
Mov Disord Clin Pract
; 2024 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-38659282
ABSTRACT
BACKGROUND:
A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity.OBJECTIVES:
To replicate and improve the 4-item MSA-P score.METHODS:
We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up.RESULTS:
The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range 0-6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity.CONCLUSIONS:
The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Mov Disord Clin Pract
Año:
2024
Tipo del documento:
Article
País de afiliación:
Austria