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Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination.
Watson, Robert A; Ye, Weiyu; Taylor, Chelsea A; Jungkurth, Elsita; Cooper, Rosalin; Tong, Orion; James, Tim; Shine, Brian; Hofer, Monika; Jenkins, Damian; Pell, Robert; Ieremia, Eleni; Jones, Stephanie; Maldonado-Perez, David; Roberts, Ian S D; Coupe, Nicholas; Middleton, Mark R; Payne, Miranda J; Fairfax, Benjamin P.
Afiliación
  • Watson RA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Ye W; Department of Oncology, University of Oxford, Oxford, UK.
  • Taylor CA; Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Jungkurth E; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Cooper R; Department of Oncology, University of Oxford, Oxford, UK.
  • Tong O; Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • James T; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Shine B; Department of Oncology, University of Oxford, Oxford, UK.
  • Hofer M; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Jenkins D; Department of Oncology, University of Oxford, Oxford, UK.
  • Pell R; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Ieremia E; Department of Oncology, University of Oxford, Oxford, UK.
  • Jones S; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Maldonado-Perez D; Department of Oncology, University of Oxford, Oxford, UK.
  • Roberts ISD; Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Coupe N; Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Middleton MR; Department of Neuro Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Payne MJ; Department of Clinical Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Fairfax BP; Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
J Immunother Cancer ; 12(4)2024 Apr 24.
Article en En | MEDLINE | ID: mdl-38663935
ABSTRACT
We describe three cases of critical acute myositis with myocarditis occurring within 22 days of each other at a single institution, all within 1 month of receiving the initial cycle of the anti-PD-1 drug pembrolizumab. Analysis of T cell receptor repertoires from peripheral blood and tissues revealed a high degree of clonal expansion and public clones between cases, with several T cell clones expanded within the skeletal muscle putatively recognizing viral epitopes. All patients had recently received a COVID-19 mRNA booster vaccine prior to treatment and were positive for SARS-CoV2 Spike antibody. In conclusion, we report a series of unusually severe myositis and myocarditis following PD-1 blockade and the COVID-19 mRNA vaccination.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / SARS-CoV-2 / COVID-19 / Miocarditis / Miositis Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Immunother Cancer Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / SARS-CoV-2 / COVID-19 / Miocarditis / Miositis Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Immunother Cancer Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido