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Development of an Innovative Biosensor Based on Graphene/PEDOT/Tyrosinase for the Detection of Phenolic Compounds in River Waters.
Bounegru, Alexandra Virginia; Iticescu, Catalina; Georgescu, Lucian P; Apetrei, Constantin.
Afiliación
  • Bounegru AV; Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galați, Romania.
  • Iticescu C; Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galați, Romania.
  • Georgescu LP; Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galați, Romania.
  • Apetrei C; Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, "Dunarea de Jos" University of Galati, 47 Domneasca Street, 800008 Galați, Romania.
Int J Mol Sci ; 25(8)2024 Apr 17.
Article en En | MEDLINE | ID: mdl-38674004
ABSTRACT
Phenolic compounds, originating from industrial, agricultural, and urban sources, can leach into flowing waters, adversely affecting aquatic life, biodiversity, and compromising the quality of drinking water, posing potential health hazards to humans. Thus, monitoring and mitigating the presence of phenolic compounds in flowing waters are essential for preserving ecosystem integrity and safeguarding public health. This study explores the development and performance of an innovative sensor based on screen-printed electrode (SPE) modified with graphene (GPH), poly(3,4-ethylenedioxythiophene) (PEDOT), and tyrosinase (Ty), designed for water analysis, focusing on the manufacturing process and the obtained electroanalytical results. The proposed biosensor (SPE/GPH/PEDOT/Ty) was designed to achieve a high level of precision and sensitivity, as well as to allow efficient analytical recoveries. Special attention was given to the manufacturing process and optimization of the modifying elements' composition. This study highlights the potential of the biosensor as an efficient and reliable solution for water analysis. Modification with graphene, the synthesis and electropolymerization deposition of the PEDOT polymer, and tyrosinase immobilization contributed to obtaining a high-performance and robust biosensor, presenting promising perspectives in monitoring the quality of the aquatic environment. Regarding the electroanalytical experimental results, the detection limits (LODs) obtained with this biosensor are extremely low for all phenolic compounds (8.63 × 10-10 M for catechol, 7.72 × 10-10 M for 3-methoxycatechol, and 9.56 × 10-10 M for 4-methylcatechol), emphasizing its ability to accurately measure even subtle variations in the trace compound parameters. The enhanced sensitivity of the biosensor facilitates detection and quantification in river water samples. Analytical recovery is also an essential aspect, and the biosensor presents consistent and reproducible results. This feature significantly improves the reliability and usefulness of the biosensor in practical applications, making it suitable for monitoring industrial or river water.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenoles / Polímeros / Contaminantes Químicos del Agua / Técnicas Biosensibles / Monofenol Monooxigenasa / Compuestos Bicíclicos Heterocíclicos con Puentes / Ríos / Grafito Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rumanía

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenoles / Polímeros / Contaminantes Químicos del Agua / Técnicas Biosensibles / Monofenol Monooxigenasa / Compuestos Bicíclicos Heterocíclicos con Puentes / Ríos / Grafito Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rumanía