Can Twisted Double Bonds Facilitate Stepwise [2 + 2] Cycloadditions?
Org Lett
; 26(18): 3778-3783, 2024 May 10.
Article
en En
| MEDLINE
| ID: mdl-38684005
ABSTRACT
Computational studies for a series of low to high strain anti-Bredt alkenes suggest that those with highly twisted bridgehead double bonds and a small singlet-triplet energy gap may undergo facile stepwise [2 + 2] cycloadditions to furnish four membered rings. A selection of reaction substrates, including ethylene, acetylene, perfluoroethylene, and cyclooctyne are considered.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos