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Association between Usage of Prophylactic AYUSH Medicines and Disease Severity in COVID-19 Patients: A Retrospective Cohort Study.
Chaudhary, Anupriya; Nayak, Debadatta; Pandey, Swati; Shastri, Vipul; Kamble, Madhuri; Pendse, Vidya; Prajapati, Vismay; Vaidya, Brijesh; Rohit, Heenal; Beedmani, Swaroopa; Presswala, Nutan; Patole, Tejaswini; Bawaskar, Ramesh; Shinde, Vaishali; Datta, Mohua; Rai, Gunjan; Prusty, Umakanta; Pal, Partha Pratim; Goli, Siva Prasad; Sahoo, Amulya Ratna; Muraleedharan, K C; Prakash, Pooja; Mahajan, Ashish; Singh, Anuradha; Krishnan, Reetha; Pawaskar, Navin; Srivastava, Amit; Ningthoujam, Gouri Devi; Sadarla, Ravi Kumar; Sonny, Ranjit; Karso, Liyi; Sarkar, Subhamoy; Prasad, Sunil; Shrivastava, Ashish Kumar; Kumar, Avinash; Kumar, Nitesh; Raveendar, Ch; Kumar, Bsj Raja; Sastry, Vspk; Dasari, Asha; Sundeep, K Samson; Kaushik, Subhash; Rath, Padmalaya; Gautam, Shweta; Shil, Ratan Chandra; Swain, Trupti Laxmi; Reddy, G Ravi Chandra; Pradeep, S; Stevenson, S; Choubey, Gurudev.
Afiliación
  • Chaudhary A; Department of Clinical Research, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Nayak D; Epidemic Cell, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Pandey S; Department of Clinical Research, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Shastri V; Department of Pathology, Vidhyadeep Homeopathic Medical College, Surat, Gujarat, India.
  • Kamble M; Department of Gynaecology, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Pendse V; Department of F.M.T, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Prajapati V; Department of Organon and Homeopathic Philosophy, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Vaidya B; Department of Physiology, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Rohit H; Department of Anatomy, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Beedmani S; Department of Gynaecology, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Presswala N; Department of Community Medicine, C.D. Pachchigar Homeopathic Medical College, Surat, Gujarat, India.
  • Patole T; Department of Clinical Research, Regional Research Institute (Homeopathy), Mumbai, Maharashtra, India.
  • Bawaskar R; Department of Clinical Research, Regional Research Institute (Homeopathy), Mumbai, Maharashtra, India.
  • Shinde V; Department of Clinical Research, Regional Research Institute (Homeopathy), Mumbai, Maharashtra, India.
  • Datta M; Department of Clinical Research, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Rai G; Department of Clinical Research, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Prusty U; Department of Clinical Research, Drug Proving Unit (H), Bhubaneswar, Odisha, India.
  • Pal PP; Department of Clinical Research, Dr Anjali Chatterjee Regional Research Institute (H), Kolkata, West Bengal, India.
  • Goli SP; Department of Clinical Research, Homeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, India.
  • Sahoo AR; Department of Clinical Research, Regional Research Institute (Homeopathy), Guwahati, Assam, India.
  • Muraleedharan KC; Department of Clinical Research, National Homeopathy Research Institute in Mental Health, Kottayam, Kerala, India.
  • Prakash P; Department of Clinical Research, National Homeopathy Research Institute in Mental Health, Kottayam, Kerala, India.
  • Mahajan A; Department of Clinical Research, Central Research Institute Homeopathy, Jaipur, Rajasthan, India.
  • Singh A; Department of Clinical Research, Central Research Institute Homeopathy, Jaipur, Rajasthan, India.
  • Krishnan R; Department of Homeopathy, Ariv Integrative Healthcare, Yashoda Hospital, Hyderabad, Telangana, India.
  • Pawaskar N; Department of Practice of Medicine, JIMS Homeopathic Medical College, Telangana, India.
  • Srivastava A; Department of Clinical Research, Regional Research Institute for Homeopathy, Imphal, Manipur, India.
  • Ningthoujam GD; Department of Clinical Research, Regional Research Institute for Homeopathy, Imphal, Manipur, India.
  • Sadarla RK; Department of Clinical Research, Clinical Research Unit for Homeopathy, Puducherry, India.
  • Sonny R; Department of Clinical Research, Regional Research Institute for Homeopathy, Siliguri, West Bengal, India.
  • Karso L; Department of Clinical Research, Regional Research Institute (Homeopathy), Guwahati, Assam, India.
  • Sarkar S; Department of Clinical Research, Regional Research Institute (Homeopathy), Guwahati, Assam, India.
  • Prasad S; Department of Clinical Research, Clinical Research Unit for Homeopathy, Ranchi, Jharkhand, India.
  • Shrivastava AK; Department of Clinical Research, Clinical Research Unit for Homeopathy, Ranchi, Jharkhand, India.
  • Kumar A; Department of Clinical Research, Clinical Research Unit for Homeopathy, Ranchi, Jharkhand, India.
  • Kumar N; Department of Clinical Research, Clinical Research Unit for Homeopathy, Ranchi, Jharkhand, India.
  • Raveendar C; Department of Clinical Research, Regional Research Institute for Homeopathy, Gudivada, Andhra Pradesh, India.
  • Kumar BR; Department of Clinical Research, Regional Research Institute for Homeopathy, Gudivada, Andhra Pradesh, India.
  • Sastry V; Department of Clinical Research, Regional Research Institute for Homeopathy, Gudivada, Andhra Pradesh, India.
  • Dasari A; Department of Clinical Research, Regional Research Institute for Homeopathy, Gudivada, Andhra Pradesh, India.
  • Sundeep KS; Department of Clinical Research, Regional Research Institute for Homeopathy, Gudivada, Andhra Pradesh, India.
  • Kaushik S; Department of Clinical Research, Central Council for Research in Homeopathy Headquarters, Delhi, India.
  • Rath P; Department of Clinical Research, Dr DP Rastogi Central Research Institute for Homeopathy, Noida, Uttar Pradesh, India.
  • Gautam S; Department of Clinical Research, Dr DP Rastogi Central Research Institute for Homeopathy, Noida, Uttar Pradesh, India.
  • Shil RC; Department of Clinical Research, Regional Research Institute of Homeopathy, Agartala, Tripura, India.
  • Swain TL; Department of Clinical Research, Regional Research Institute of Homeopathy, Agartala, Tripura, India.
  • Reddy GRC; Department of Clinical Research, Clinical Research Unit Homeopathy, Tirupati, Andhra Pradesh, India.
  • Pradeep S; Department of Clinical Research, Clinical Research Unit Homeopathy, Tirupati, Andhra Pradesh, India.
  • Stevenson S; Department of Clinical Research, Clinical Research Unit Homeopathy, Tirupati, Andhra Pradesh, India.
  • Choubey G; Department of Clinical Research, Regional Research Institute for Homeopathy, Siliguri, West Bengal, India.
Homeopathy ; 2024 May 07.
Article en En | MEDLINE | ID: mdl-38714214
ABSTRACT

BACKGROUND:

Prior vaccination is often studied for its impact on individuals' post-infection prognosis. Ayurveda, Yoga, Unani, Siddha and Homeopathy (AYUSH) medicines, advised by the Government of India as prophylaxis during the first wave of the coronavirus disease 2019 (COVID-19) pandemic, were consumed by the masses in 2020. A study was therefore undertaken to observe any association between the prior usage of AYUSH prophylactic medicines and post-infection severity as reported by recovered COVID-19 individuals.

METHODS:

This was a retrospective, multi-centre, cohort study conducted in 21 cities of India from 5th August to 30th November 2020. Data from recovered COVID-19 patients, of either sex or any age, captured information about AYUSH prophylactic medicines intake prior to infection, disease severity, symptomatology, duration of complaints, etc. The study participants were grouped into AYUSH intake and non-intake. Primary composite outcome was the disease clinical course. Secondary clinical outcomes were the rate of and time to clinical recovery.

RESULTS:

Data of 5,023 persons were analysed. Ayurveda or homeopathic prophylactic medicines were consumed by more than half of the study

participants:

that is, 56.85% (n = 1,556) and 56.81% (n = 1,555) respectively. The overall adjusted protective effect (PE) of AYUSH prophylactic intake against moderate/severe forms of COVID-19 disease was 56.7% (95% confidence interval [CI], 48.7 to 63.50; p < 0.001). Adjusted PE for homeopathy and Siddha was 52.9% (95% CI, 42.30 to 61.50; p < 0.001) and 59.8% (95% CI, 37.80 to 74.10; p < 0.001), respectively. A statistically significant association was found between AYUSH prophylactic medicine intake and clinical recovery more frequently by the 3rd day of illness (χ2 = 9.01; p = 0.002). Time to resolution of symptoms in the AYUSH intake group was on average 0.3 days earlier than in the non-intake group (p = 0.002).

CONCLUSION:

AYUSH prophylactics were associated with statistically significant levels of protection against COVID-19 disease severity. Amongst these, previous intake of homeopathy or Siddha medicines was associated with some protection against moderate/severe illness and with a somewhat quicker clinical recovery. Prospective studies with experimental research design are needed to validate the findings of this study. STUDY REGISTRATION Clinical Trials Registry-India (CTRI/2020/08/027000).

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Homeopathy Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Homeopathy Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: India