Enpp2 haploinsufficiency induces an eye-open-at-birth phenotype in the DBA/2 background.
MicroPubl Biol
; 20242024.
Article
en En
| MEDLINE
| ID: mdl-38725939
ABSTRACT
Autotaxin, encoded by the Enpp2 gene, produces lysophosphatidic acid (LPA), which exerts numerous biological functions via its cognate receptors. Enpp2 null mutant mice die by embryonic day 9.5 owing to aberrant vascular development in the yolk sac, preventing analysis after that period. In this study, we found that Enpp2 heterozygous mice in the DBA/2 genetic background showed an eye-open-at-birth phenotype at high frequency, caused by failure of eyelid closure during the embryonic stage. Notably, wildtype pups from the Enpp2 heterozygous dam showed the phenotype, although at lower frequency, suggesting that maternal LPA affects the embryonic development.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
MicroPubl Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón