The protective effect of Astaxanthin on scopolamine - induced Alzheimer's model in mice.
Neurosciences (Riyadh)
; 29(2): 103-112, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38740397
ABSTRACT
OBJECTIVES:
To investigate the fundamental mechanisms of the neuroprotective impact of Astaxanthin (AST) in a mouse model of Alzheimer's disease (AD) induced by scopolamine.METHODS:
This research constituted an in vivo animal study encompassing 36 adult male mice, divided into 6 groups Control, 100 mg/kg AST, 2 mg/kg scopolamine (AD group), 100 mg/kg AST+2 mg/kg scopolamine, 3 mg/kg galantamine+2 mg/kg scopolamine, and 100 mg/kg AST+3 mg/kg galantamine+2 mg/kg scopolamine. After 14 days, the mice's short-term memory, hippocampus tissue, oxidative and inflammatory markers were evaluated.RESULTS:
The AST demonstrated a beneficial influence on short-term memory and a reduction in acetylcholinesterase activity in the brain. It exhibited neuroprotective and anti-amyloidogenic properties, significantly decreased pro-inflammatory markers and oxidative stress, and reversed the decline of the Akt-1 and phosphorylated Akt pathway, a crucial regulator of abnormal tau. Furthermore, AST enhanced the effect of galantamine in reducing inflammation and oxidative stress.CONCLUSION:
The findings indicate that AST may offer therapeutic benefits against cognitive dysfunction in AD. This is attributed to its ability to reduce oxidative stress, control neuroinflammation, and enhance Akt-1 and pAkt levels, thereby underscoring its potential in AD treatment strategies.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Escopolamina
/
Estrés Oxidativo
/
Fármacos Neuroprotectores
/
Xantófilas
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Modelos Animales de Enfermedad
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Enfermedad de Alzheimer
Límite:
Animals
Idioma:
En
Revista:
Neurosciences (Riyadh)
Asunto de la revista:
NEUROLOGIA
Año:
2024
Tipo del documento:
Article