Metastatic triple-negative breast carcinoma mimicking melanoma: A potential diagnostic pitfall.
J Cutan Pathol
; 51(9): 654-657, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38767140
ABSTRACT
Melanoma, with its diverse histopathologic characteristics, can mimic both benign nevi and neoplasms of various cell lineages. Immunohistochemistry (IHC) can play a vital role in melanoma diagnosis, particularly when the cell lineage is unclear on hematoxylin and eosin sections. Commonly utilized IHC stains for melanoma diagnosis include SOX10, Melan-A, and S100. A relatively novel stain, PReferentially expressed Antigen in MElanoma (PRAME), is also proving useful in accurate melanoma diagnosis. However, none of these stains are completely specific to melanocytes or melanoma, and misinterpretation can lead to incorrect diagnoses. This report presents a unique case of triple-negative breast carcinoma (TNBC) metastatic to the skin exhibiting histopathologic characteristics similar to melanoma, including positivity for SOX10 and PRAME. Our aim is to highlight TNBC metastatic to the skin as a potential diagnostic pitfall.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Factores de Transcripción SOXE
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Neoplasias de la Mama Triple Negativas
/
Melanoma
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos