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In-cell chemical construction of a photoswitchable CENP-E using a photochromic covalent inhibitor.
Matsuo, Kazuya; Yamaoka, Shusuke; Waku, Tomonori; Kobori, Akio.
Afiliación
  • Matsuo K; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. kmatsuo@kit.ac.jp.
  • Yamaoka S; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. kmatsuo@kit.ac.jp.
  • Waku T; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. kmatsuo@kit.ac.jp.
  • Kobori A; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. kmatsuo@kit.ac.jp.
Org Biomol Chem ; 22(23): 4651-4655, 2024 06 12.
Article en En | MEDLINE | ID: mdl-38787760
ABSTRACT
An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled to local control of mitotic cell division with light illumination.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Japón