PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury.

Michel-Flutot, Pauline; Cheng, Lan; Thomas, Samantha J; Lisi, Brianna; Schwartz, Harrison; Lam, Sandy; Lyttle, Megan; Jaffe, David A; Smith, George; Li, Shuxin; Wright, Megan C; Lepore, Angelo C

Michel-Flutot, Pauline; Cheng, Lan; Thomas, Samantha J; Lisi, Brianna; Schwartz, Harrison; Lam, Sandy; Lyttle, Megan; Jaffe, David A; Smith, George; Li, Shuxin; Wright, Megan C; Lepore, Angelo C.

Afiliación

Michel-Flutot P; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cheng L; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Thomas SJ; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lisi B; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Schwartz H; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lam S; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lyttle M; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jaffe DA; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Smith G; Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 191405104, USA.
Li S; Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 191405104, USA.
Wright MC; Department of Biology, Arcadia University, Glenside, PA 19038, USA.
Lepore AC; Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: angelo.lepore@jefferson.edu.

Exp Neurol ; 378: 114816, 2024 Aug.

Article en En | MEDLINE | ID: mdl-38789023

Asunto(s)

Axones; Diafragma; Fosfohidrolasa PTEN; Recuperación de la Función; Traumatismos de la Médula Espinal; Animales; Femenino; Ratas; Axones/efectos de los fármacos; Médula Cervical/lesiones; Enfermedad Crónica; Diafragma/inervación; Modelos Animales de Enfermedad; Fosfohidrolasa PTEN/antagonistas & inhibidores; Fosfohidrolasa PTEN/metabolismo; Ratas Sprague-Dawley; Proteínas Tirosina Fosfatasas Clase 2 Similares a Receptores/antagonistas & inhibidores; Proteínas Tirosina Fosfatasas Clase 2 Similares a Receptores/metabolismo; Recuperación de la Función/fisiología; Recuperación de la Función/efectos de los fármacos; Traumatismos de la Médula Espinal/fisiopatología; Traumatismos de la Médula Espinal/patología

Palabras clave

Axon; Breathing; Cervical; Chronic; Circuit; Contusion; Diaphragm; PTEN; PTPsigma; Regeneration; Respiratory; SCI; Spinal cord injury; Sprouting

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Axones / Diafragma / Recuperación de la Función / Fosfohidrolasa PTEN Límite: Animals Idioma: En Revista: Exp Neurol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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