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Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration.
Lu, Gengxi; Gong, Chen; Sun, Yizhe; Qian, Xuejun; Rajendran Nair, Deepthi S; Li, Runze; Zeng, Yushun; Ji, Jie; Zhang, Junhang; Kang, Haochen; Jiang, Laiming; Chen, Jiawen; Chang, Chi-Feng; Thomas, Biju B; Humayun, Mark S; Zhou, Qifa.
Afiliación
  • Lu G; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Gong C; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Sun Y; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Qian X; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Rajendran Nair DS; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Li R; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Zeng Y; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Ji J; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Zhang J; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Kang H; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Jiang L; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Chen J; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Chang CF; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Thomas BB; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Humayun MS; Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Zhou Q; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Nat Commun ; 15(1): 4481, 2024 May 27.
Article en En | MEDLINE | ID: mdl-38802397
ABSTRACT
Retinal degeneration, a leading cause of irreversible low vision and blindness globally, can be partially addressed by retina prostheses which stimulate remaining neurons in the retina. However, existing electrode-based treatments are invasive, posing substantial risks to patients and healthcare providers. Here, we introduce a completely noninvasive ultrasonic retina prosthesis, featuring a customized ultrasound two-dimensional array which allows for simultaneous imaging and stimulation. With synchronous three-dimensional imaging guidance and auto-alignment technology, ultrasonic retina prosthesis can generate programmed ultrasound waves to dynamically and precisely form arbitrary wave patterns on the retina. Neuron responses in the brain's visual center mirrored these patterns, evidencing successful artificial vision creation, which was further corroborated in behavior experiments. Quantitative analysis of the spatial-temporal resolution and field of view demonstrated advanced performance of ultrasonic retina prosthesis and elucidated the biophysical mechanism of retinal stimulation. As a noninvasive blindness prosthesis, ultrasonic retina prosthesis could lead to a more effective, widely acceptable treatment for blind patients. Its real-time imaging-guided stimulation strategy with a single ultrasound array, could also benefit ultrasound neurostimulation in other diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retina / Ceguera / Prótesis Visuales Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retina / Ceguera / Prótesis Visuales Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos