A bioprinted sea-and-island multicellular model for dissecting human pancreatic tumor-stroma reciprocity and adaptive metabolism.

Li, Ming; Freeman, Sebastian; Franco-Barraza, Janusz; Cai, Kathy Q; Kim, Amy; Jin, Sha; Cukierman, Edna; Ye, Kaiming

Li, Ming; Freeman, Sebastian; Franco-Barraza, Janusz; Cai, Kathy Q; Kim, Amy; Jin, Sha; Cukierman, Edna; Ye, Kaiming.

Afiliación

Li M; Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, SUNY, Binghamton, NY, USA.
Freeman S; Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, SUNY, Binghamton, NY, USA.
Franco-Barraza J; Cancer Signaling and Microenvironment Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Lewis Katz Temple School of Medicine, Philadelphia, PA, USA.
Cai KQ; Cancer Signaling and Microenvironment Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Lewis Katz Temple School of Medicine, Philadelphia, PA, USA.
Kim A; Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, SUNY, Binghamton, NY, USA.
Jin S; Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, SUNY, Binghamton, NY, USA.
Cukierman E; Cancer Signaling and Microenvironment Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Lewis Katz Temple School of Medicine, Philadelphia, PA, USA. Electronic address: Edna.Cukierman@fccc.edu.
Ye K; Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, SUNY, Binghamton, NY, USA. Electronic address: kye@binghamton.edu.

Biomaterials ; 310: 122631, 2024 Oct.

Article en En | MEDLINE | ID: mdl-38815457

Asunto(s)

Carcinoma Ductal Pancreático; Matriz Extracelular; Neoplasias Pancreáticas; Microambiente Tumoral; Humanos; Neoplasias Pancreáticas/patología; Neoplasias Pancreáticas/metabolismo; Carcinoma Ductal Pancreático/patología; Carcinoma Ductal Pancreático/metabolismo; Matriz Extracelular/metabolismo; Línea Celular Tumoral; Impresión Tridimensional; Fibroblastos Asociados al Cáncer/metabolismo; Fibroblastos Asociados al Cáncer/patología; Bioimpresión/métodos; Células del Estroma/metabolismo; Células del Estroma/patología; Modelos Biológicos

Palabras clave

3D bioprinting; Cancer adaptive metabolism; Cancer-associated fibroblast; Extracellular matrix modification; Multicellular tumor model; Pancreatic ductal adenocarcinoma; Proteomics; Tumor-stroma reciprocity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Matriz Extracelular / Microambiente Tumoral Límite: Humans Idioma: En Revista: Biomaterials Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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