Might procalcitonin help predict imported falciparum malaria in children?
Travel Med Infect Dis
; 60: 102731, 2024.
Article
en En
| MEDLINE
| ID: mdl-38821330
ABSTRACT
BACKGROUND:
Procalcitonin (PCT) has been proposed as a marker for malaria severity in adults, with a threshold of 10 ng/ml for severe falciparum disease. Whether PCT is useful in children is debated. PATIENTS &METHODS:
A retrospective case-control study was conducted to compare initial PCT levels in children with uncomplicated malaria and a control group, and between children with uncomplicated and severe malaria.RESULTS:
Results showed significantly higher PCT levels in malaria cases compared to the control group and in malaria severe cases compared to uncomplicated cases. A Receiving Operator Characteristic curve established a PCT threshold of 0.65 ng/ml with a negative predictive value of 98.8 % based on a prevalence of 10 %. Analyzing the pooled results of five studies suggested a threshold of 6.17 ng/ml for differentiating uncomplicated and severe malaria.CONCLUSION:
PCT might be a useful tool to help rule out malaria and predict potential disease severity in returning travelers.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Malaria Falciparum
/
Polipéptido alfa Relacionado con Calcitonina
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
Idioma:
En
Revista:
Travel Med Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia