Furostanol glycosides, stilbenoids and nucleosides from the roots of Smilax perfoliata, and evaluation of their cytotoxic and anticholinesterase activities.
Nat Prod Res
; : 1-11, 2024 Jun 04.
Article
en En
| MEDLINE
| ID: mdl-38832521
ABSTRACT
Three undescribed compounds including two furosteroid glycosides (perfoloside and 22-O-methylperfoloside) and one stilbenedimer (perfolostilbene) together with 21 known compounds were isolated from the roots of Smilax perfoliata. The structural elucidation was established by extensive uses of HRMS, 1D and 2D spectroscopic techniques. The assignment of the stereocenters in perfolostilbene was based on NOESY data and ECD calculation. Among the isolates, two compounds showed marginal cytotoxic activity against KB and Hela cell lines while seven stilbenoids showed strong to weak antiacetylcholinesterase and antibutyrylcholinesterase activities with IC50 ranging between 2-197 µM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Nat Prod Res
/
Nat. prod. res. (Online)
/
Natural product research (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Tailandia