Effect of zinc supplementation on glycemic biomarkers: an umbrella of interventional meta-analyses.
Diabetol Metab Syndr
; 16(1): 124, 2024 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-38849958
ABSTRACT
BACKGROUND:
Several studies have evaluated the effects of zinc supplementation on glycemic biomarkers in humans and have demonstrated varying results. We systematically evaluated the literature and performed an umbrella meta-analysis of the effects of zinc supplementation on type 2 diabetes biomarkers.METHODS:
A comprehensive literature search was conducted in the following databases; PubMed, Embase, Embase, Cochrane Library, Scopus, and Web of Science for studies published up to March 10, 2024.RESULTS:
Zinc supplementation was effective in reducing serum FBS (WMD - 13.58, 95% CI - 17.38, - 9.77; p < 0.001; SMD - 0.52, 95% CI - 0.79, - 0.25; p = < 0.001), insulin (SMD - 0.67, 95% CI - 0.96, - 0.38; p < 0.001), HOMA-IR levels (WMD - 0.52, 95% CI - 0.66, - 0.38; p < 0.001; SMD - 0.78, 95% CI - 1.02, - 0.42; p < 0.001), and HbA1c (WMD - 0.35, 95% CI - 0.43, - 0.27; p < 0.001).CONCLUSION:
Zinc supplementation significantly reduced FBS, HOMA-IR, insulin and HbA1c. These findings suggest that zinc is potentially an effective complementary intervention to improve type 2 diabetes biomarkers.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Diabetol Metab Syndr
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán