Genetic-informed proteome-wide scan reveals potential causal plasma proteins for idiopathic pulmonary fibrosis.
Thorax
; 79(9): 878-882, 2024 Aug 19.
Article
en En
| MEDLINE
| ID: mdl-38871465
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which there are no reliable biomarkers or disease-modifying drugs. Here, we integrated human genomics and proteomics to investigate the causal associations between 2769 plasma proteins and IPF. Our Mendelian randomisation analysis identified nine proteins associated with IPF, of which three (FUT3, ADAM15 and USP28) were colocalised. ADAM15 emerged as the top candidate, supported by expression quantitative trait locus analysis in both blood and lung tissue. These findings provide novel insights into the aetiology of IPF and offer translational opportunities in response to the clinical challenges of this devastating disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Sanguíneas
/
Proteoma
/
Fibrosis Pulmonar Idiopática
Límite:
Humans
Idioma:
En
Revista:
Thorax
Año:
2024
Tipo del documento:
Article
País de afiliación:
China