Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34.
Oncoimmunology
; 13(1): 2364958, 2024.
Article
en En
| MEDLINE
| ID: mdl-38872753
ABSTRACT
We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Fosfatidilinositol 3-Quinasas Clase III
/
Proteínas de la Membrana
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Oncoimmunology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Luxemburgo