Engineered heart tissue: Design considerations and the state of the art.
Biophys Rev (Melville)
; 5(2): 021308, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38912258
ABSTRACT
Originally developed more than 20 years ago, engineered heart tissue (EHT) has become an important tool in cardiovascular research for applications such as disease modeling and drug screening. Innovations in biomaterials, stem cell biology, and bioengineering, among other fields, have enabled EHT technologies to recapitulate many aspects of cardiac physiology and pathophysiology. While initial EHT designs were inspired by the isolated-trabecula culture system, current designs encompass a variety of formats, each of which have unique strengths and limitations. In this review, we describe the most common EHT formats, and then systematically evaluate each aspect of their design, emphasizing the rational selection of components for each application.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Biophys Rev (Melville)
Año:
2024
Tipo del documento:
Article