Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024.

Patel, Mira C; Nguyen, Ha T; Pascua, Philippe Noriel Q; Gao, Rongyuan; Steel, John; Kondor, Rebecca J; Gubareva, Larisa V

Patel, Mira C; Nguyen, Ha T; Pascua, Philippe Noriel Q; Gao, Rongyuan; Steel, John; Kondor, Rebecca J; Gubareva, Larisa V.

Emerg Infect Dis ; 30(7): 1410-1415, 2024 Jul.

Article en En | MEDLINE | ID: mdl-38916572

ABSTRACT

ABSTRACT

Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.

Asunto(s)

Antivirales; Farmacorresistencia Viral; Subtipo H1N1 del Virus de la Influenza A; Gripe Humana; Neuraminidasa; Oseltamivir; Filogenia; Oseltamivir/farmacología; Oseltamivir/uso terapéutico; Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H1N1 del Virus de la Influenza A/genética; Humanos; Antivirales/farmacología; Antivirales/uso terapéutico; Gripe Humana/virología; Gripe Humana/tratamiento farmacológico; Gripe Humana/epidemiología; Neuraminidasa/antagonistas & inhibidores; Neuraminidasa/genética; Farmacorresistencia Viral/genética; Mutación

Palabras clave

H1N1; Influenza; United States; antimicrobial resistance; antiviral; baloxavir; influenza A(H1N1)pdm09; neuraminidase inhibitors; oseltamivir; pH1N1; phenotypic testing; reduced inhibition; substitution; viruses

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Filogenia / Farmacorresistencia Viral / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A / Oseltamivir / Neuraminidasa Límite: Humans Idioma: En Revista: Emerg Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article

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