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Dietary Inulin to Improve SARS-CoV-2 Vaccine Response in Kidney Transplant Recipients: The RIVASTIM-Inulin Randomised Controlled Trial.
Singer, Julian; Tunbridge, Matthew J; Shi, Bree; Perkins, Griffith B; Chai, Cheng Sheng; Salehi, Tania; Sim, Beatrice Z; Kireta, Svjetlana; Johnston, Julie K; Akerman, Anouschka; Milogiannakis, Vanessa; Aggarwal, Anupriya; Turville, Stuart; Hissaria, Pravin; Ying, Tracey; Wu, Huiling; Grubor-Bauk, Branka; Coates, P Toby; Chadban, Steven J.
Afiliación
  • Singer J; Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
  • Tunbridge MJ; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
  • Shi B; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Perkins GB; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
  • Chai CS; Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
  • Salehi T; Immunology Directorate, SA Pathology, Adelaide, SA 5000, Australia.
  • Sim BZ; Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
  • Kireta S; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Johnston JK; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Akerman A; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Milogiannakis V; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Aggarwal A; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Turville S; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Hissaria P; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Ying T; Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
  • Wu H; Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.
  • Grubor-Bauk B; Department of Immunology and Allergy, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
  • Coates PT; Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia.
  • Chadban SJ; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
Vaccines (Basel) ; 12(6)2024 Jun 03.
Article en En | MEDLINE | ID: mdl-38932337
ABSTRACT
Kidney transplant recipients are at an increased risk of hospitalisation and death from SARS-CoV-2 infection, and standard two-dose vaccination schedules are typically inadequate to generate protective immunity. Gut dysbiosis, which is common among kidney transplant recipients and known to effect systemic immunity, may be a contributing factor to a lack of vaccine immunogenicity in this at-risk cohort. The gut microbiota modulates vaccine responses, with the production of immunomodulatory short-chain fatty acids by bacteria such as Bifidobacterium associated with heightened vaccine responses in both observational and experimental studies. As SCFA-producing populations in the gut microbiota are enhanced by diets rich in non-digestible fibre, dietary supplementation with prebiotic fibre emerges as a potential adjuvant strategy to correct dysbiosis and improve vaccine-induced immunity. In a randomised, double-bind, placebo-controlled trial of 72 kidney transplant recipients, we found dietary supplementation with prebiotic inulin for 4 weeks before and after a third SARS-CoV2 mRNA vaccine to be feasible, tolerable, and safe. Inulin supplementation resulted in an increase in gut Bifidobacterium, as determined by 16S RNA sequencing, but did not increase in vitro neutralisation of live SARS-CoV-2 virus at 4 weeks following a third vaccination. Dietary fibre supplementation is a feasible strategy with the potential to enhance vaccine-induced immunity and warrants further investigation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Australia