Histoplasmosis: A systematic review to inform the World Health Organization of a fungal priority pathogens list.
Med Mycol
; 62(6)2024 Jun 27.
Article
en En
| MEDLINE
| ID: mdl-38935903
ABSTRACT
Histoplasmosis, a significant mycosis primarily prevalent in Africa, North and South America, with emerging reports globally, poses notable health challenges, particularly in immunocompromised individuals such as people living with HIV/AIDS and organ transplant recipients. This systematic review, aimed at informing the World Health Organization's Fungal Priority Pathogens List, critically examines literature from 2011 to 2021 using PubMed and Web of Science, focusing on the incidence, mortality, morbidity, antifungal resistance, preventability, and distribution of Histoplasma. We also found a high prevalence (22%-44%) in people living with HIV, with mortality rates ranging from 21% to 53%. Despite limited data, the prevalence of histoplasmosis seems stable, with lower estimates in Europe. Complications such as central nervous system disease, pulmonary issues, and lymphoedema due to granuloma or sclerosis are noted, though their burden remains uncertain. Antifungal susceptibility varies, particularly against fluconazole (MIC ≥32 mg/l) and caspofungin (MICs 4-32 mg/l), while resistance to amphotericin B (MIC 0.125-0.16 mg/l), itraconazole (MICs 0.004-0.125 mg/l), and voriconazole (MICs 0.004-0.125 mg/l) remains low. This review identifies critical knowledge gaps, underlining the need for robust, globally representative surveillance systems to better understand and combat this fungal threat.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Organización Mundial de la Salud
/
Farmacorresistencia Fúngica
/
Histoplasma
/
Histoplasmosis
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
Med Mycol
Asunto de la revista:
MEDICINA VETERINARIA
/
MICROBIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Australia