Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster.
J Nutr Sci Vitaminol (Tokyo)
; 70(3): 252-261, 2024.
Article
en En
| MEDLINE
| ID: mdl-38945891
ABSTRACT
Pyridoxamine (PM) is one of the natural vitamins B6 (VB6) and functions as an endogenous inhibitor for the formation of AGEs (advanced glycation end products). The AGEs are implicated in aging, diabetes, and various neuropsychiatric disease, including schizophrenia, Alzheimer's disease, and Parkinson's disease. However, it is unclear whether the absence of PM per se accumulates AGEs in vivo and causes behavioral dysfunctions. To address these points, we raised PM-deficient fruit flies, Drosophila melanogaster, with the sterilized defined medium. Flies reared in a PM-deficient medium accumulated AGEs and reduced lifespan, impaired gustatory response, sleep, courtship behavior, and olfactory learning. These results suggest that PM suppresses AGE accumulation in vivo and is required for regulating innate and empirical behaviors.
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Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridoxamina
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Conducta Animal
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Productos Finales de Glicación Avanzada
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Drosophila melanogaster
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Longevidad
Límite:
Animals
Idioma:
En
Revista:
J Nutr Sci Vitaminol (Tokyo)
Año:
2024
Tipo del documento:
Article