Collagen in hepatocellular carcinoma: A novel biomarker and therapeutic target.
Hepatol Commun
; 8(7)2024 07 01.
Article
en En
| MEDLINE
| ID: mdl-38967581
ABSTRACT
HCC is globally recognized as a major health threat. Despite significant progress in the development of treatment strategies for liver cancer, recurrence, metastasis, and drug resistance remain key factors leading to a poor prognosis for the majority of liver cancer patients. Thus, there is an urgent need to develop effective biomarkers and therapeutic targets for HCC. Collagen, the most abundant and diverse protein in the tumor microenvironment, is highly expressed in various solid tumors and plays a crucial role in the initiation and progression of tumors. Recent studies have shown that abnormal expression of collagen in the tumor microenvironment is closely related to the occurrence, development, invasion, metastasis, drug resistance, and treatment of liver cancer, making it a potential therapeutic target and a possible diagnostic and prognostic biomarker for HCC. This article provides a comprehensive review of the structure, classification, and origin of collagen, as well as its role in the progression and treatment of HCC and its potential clinical value, offering new insights into the diagnosis, treatment, and prognosis assessment of liver cancer.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Colágeno
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Carcinoma Hepatocelular
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Microambiente Tumoral
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Neoplasias Hepáticas
Límite:
Humans
Idioma:
En
Revista:
Hepatol Commun
Año:
2024
Tipo del documento:
Article