Your browser doesn't support javascript.
loading
Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure.
Vandewouw, Marlee M; Norris-Brilliant, Ami; Rahman, Anum; Assimopoulos, Stephania; Morton, Sarah U; Kushki, Azadeh; Cunningham, Sean; King, Eileen; Goldmuntz, Elizabeth; Miller, Thomas A; Thomas, Nina H; Adams, Heather R; Cleveland, John; Cnota, James F; Ellen Grant, P; Goldberg, Caren S; Huang, Hao; Li, Jennifer S; McQuillen, Patrick; Porter, George A; Roberts, Amy E; Russell, Mark W; Seidman, Christine E; Tivarus, Madalina E; Chung, Wendy K; Hagler, Donald J; Newburger, Jane W; Panigrahy, Ashok; Lerch, Jason P; Gelb, Bruce D; Anagnostou, Evdokia.
Afiliación
  • Vandewouw MM; Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada. Electronic address: mvandewouw@hollandbloorview.ca.
  • Norris-Brilliant A; Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, USA.
  • Rahman A; Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Assimopoulos S; Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Morton SU; Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Genetics, H
  • Kushki A; Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
  • Cunningham S; Department of Pediatrics, Division of General Pediatrics, University of Utah, Salt Lake City, UT, USA.
  • King E; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH, USA.
  • Goldmuntz E; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Miller TA; Department of Pediatrics, Maine Medical Center, Portland, ME, USA.
  • Thomas NH; Department of Child and Adolescent Psychiatry and Behavioral Sciences and Center for Human Phenomic Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
  • Adams HR; Departments of Neurology and Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
  • Cleveland J; Departments of Surgery and Pediatrics, Keck School of Medicine, University of Southern California, LA, USA.
  • Cnota JF; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA; Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Ellen Grant P; Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Radiology,
  • Goldberg CS; Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
  • Huang H; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Li JS; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
  • McQuillen P; Departments of Pediatrics and Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Porter GA; Departments of Neurology and Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
  • Roberts AE; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Cardiology, Boston Children's Hospital, Boston, MA USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
  • Russell MW; Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
  • Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA, USA; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  • Tivarus ME; Department of Imaging Sciences and Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
  • Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
  • Hagler DJ; Center for Multimodal Imaging and Genetics, University of California San Diego, USA; Department of Radiology, School of Medicine, University of California San Diego, USA; Departments of Cognitive Science and Neuroscience, University of California San Diego, USA.
  • Newburger JW; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Cardiology, Boston Children's Hospital, Boston, MA USA.
  • Panigrahy A; Department of Pediatric Radiology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA USA.
  • Lerch JP; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Program in Neurosciences & Mental Health, The Hospital for Sick Children, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, O
  • Gelb BD; Mindich Child Health and Development Institute and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY USA.
  • Anagnostou E; Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Institute of Medical Science, University of
Neuroimage ; 297: 120721, 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-38968977
ABSTRACT
Individuals with congenital heart disease (CHD) have an increased risk of neurodevelopmental impairments. Given the hypothesized complexity linking genomics, atypical brain structure, cardiac diagnoses and their management, and neurodevelopmental outcomes, unsupervised methods may provide unique insight into neurodevelopmental variability in CHD. Using data from the Pediatric Cardiac Genomics Consortium Brain and Genes study, we identified data-driven subgroups of individuals with CHD from measures of brain structure. Using structural magnetic resonance imaging (MRI; N = 93; cortical thickness, cortical volume, and subcortical volume), we identified subgroups that differed primarily on cardiac anatomic lesion and language ability. In contrast, using diffusion MRI (N = 88; white matter connectivity strength), we identified subgroups that were characterized by differences in associations with rare genetic variants and visual-motor function. This work provides insight into the differential impacts of cardiac lesions and genomic variation on brain growth and architecture in patients with CHD, with potentially distinct effects on neurodevelopmental outcomes.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article