Proposal of reference value for day-to-day blood pressure variability based on two outcomes: the Ohasama study.
J Hypertens
; 2024 Jun 21.
Article
en En
| MEDLINE
| ID: mdl-38973595
ABSTRACT
BACKGROUND:
This study aimed to propose reference values for day-to-day home blood pressure (BP) variability that align with the established hypertension threshold of home BP for the risk of two differentoutcomes:
cardiovascular mortality and cognitive decline.METHODS:
This prospective study was conducted in Ohasama town, Japan, with 1212 participants assessed for cardiovascular mortality risk (age 64.7âyears, 33.6% men). Additionally, 678 participants (age 62.7âyears, 31.1% men) were assessed for cognitive decline risk (Mini-Mental Scale Examination score <24). The within-individual coefficient of variation of home morning SBP (HSBP) was used as the index of day-to-day BP variability (%). Adjusted Cox regression models were used to estimate the HSBP-CV values, which provided the 10-year outcome risk at an HSBP of 135âmmHg.RESULTS:
A total of 114 cardiovascular deaths and 85 events of cognitive decline (mean follow-up13.9 and 9.6âyears, respectively) were identified. HSBP and HSBP-coefficient of variation (HSBP-CV) were associated with increased risks for both outcomes, with adjusted hazard ratios per 1-standard deviation increase of at least 1.25 for cardiovascular mortality and at least 1.30 for cognitive decline, respectively. The adjusted 10-year risks for cardiovascular mortality and cognitive decline were 1.67 and 8.83%, respectively, for an HSBP of 135âmmHg. These risk values were observed when the HSBP-CV was 8.44 and 8.53%, respectively.CONCLUSION:
The HSBP-CV values indicating the 10-year risk of cardiovascular mortality or cognitive decline at an HSBP of 135âmmHg were consistent, at approximately 8.5%. This reference value will be useful for risk stratification in clinical practice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Hypertens
Año:
2024
Tipo del documento:
Article