Your browser doesn't support javascript.
loading
Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.
Zhou, Xin; Ganz, Ariel B; Rayner, Andre; Cheng, Tess Yan; Oba, Haley; Rolnik, Benjamin; Lancaster, Samuel; Lu, Xinrui; Li, Yizhou; Johnson, Jethro S; Hoyd, Rebecca; Spakowicz, Daniel J; Slavich, George M; Snyder, Michael P.
Afiliación
  • Zhou X; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Ganz AB; Stanford Center for Genomics and Personalized Medicine, Stanford university School of Medicine, CA, USA.
  • Rayner A; These authors contributed equally to the work.
  • Cheng TY; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Oba H; Stanford Healthcare Innovation Lab, Stanford University, CA, USA.
  • Rolnik B; These authors contributed equally to the work.
  • Lancaster S; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Lu X; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Li Y; Department of Microbiology, College of Arts and Sciences, University of Washington, WA, USA.
  • Johnson JS; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Hoyd R; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Spakowicz DJ; Stanford Healthcare Innovation Lab, Stanford University, CA, USA.
  • Slavich GM; Department of Genetics, Stanford University School of Medicine, CA, USA.
  • Snyder MP; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China.
bioRxiv ; 2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38979211
ABSTRACT

Background:

Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood.

Methods:

We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.

Results:

We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.

Conclusions:

Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos