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Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil.
de Oliveira, Pollyanne Raysa Fernandes; de Carvalho, Jamile Ambrósio; Costa, Taizi Rodrigues; Silva, Bruno Pajeú E; da Silva, Gabriela Gonçalves; Rodrigues, Anderson Messias; Mota, Rinaldo Aparecido.
Afiliación
  • de Oliveira PRF; Laboratory of Infectious Diseases, Department of Veterinary Medicine, University Federal Rural of Pernambuco (UFRPE), Recife, Brazil. pollyanne_raysa@hotmail.com.
  • de Carvalho JA; Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, 04023062, Brazil.
  • Costa TR; Laboratory of Infectious Diseases, Department of Veterinary Medicine, University Federal Rural of Pernambuco (UFRPE), Recife, Brazil.
  • Silva BPE; University Center UNIFAVIP, Caruaru, Brazil.
  • da Silva GG; Laboratory of Infectious Diseases, Department of Veterinary Medicine, University Federal Rural of Pernambuco (UFRPE), Recife, Brazil.
  • Rodrigues AM; Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, 04023062, Brazil. amrodrigues@unifesp.br.
  • Mota RA; National Institute of Science and Technology in Human Pathogenic Fungi, São Paulo, Brazil. amrodrigues@unifesp.br.
Mycopathologia ; 189(4): 66, 2024 Jul 14.
Article en En | MEDLINE | ID: mdl-39003373
ABSTRACT
Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue that affects people living in resource-poor urban centers in Brazil. The lack of knowledge about transmission dynamics makes it difficult to propose public health policies to contain the advance of sporotrichosis. We describe the recent emergence of 1,176 cases of sporotrichosis in cats (2016 to 2021) in the metropolitan region of Recife, Brazil, leading to significant zoonotic transmission and an overwhelming occurrence of S. brasiliensis as the etiological agent. Most cases were from cats in the cities of Olinda (408/1,176; 34.70%), Jaboatão dos Guararapes (332/1,176; 28.23%), and Recife (237/1,176; 20.15%). Molecular typing using amplified fragment length polymorphism (EcoRI-GA/MseI-AG) revealed low polymorphic information content (PIC = 0.2499) and heterozygosity (H = 0.2928), typical of an outbreak scenario. Dendrogram and multivariate cluster analysis revealed that isolates from Pernambuco are closely related to Rio de Janeiro isolates. We report a substantial occurrence of MAT1-2 idiomorphs in the metropolitan region of Recife (060 ratio; χ2 = 60.000, P < 0.0001). The limited population differentiation and genetic diversity of the isolates from Pernambuco suggest a recent introduction, possibly via a founder effect, from the parental population in Rio de Janeiro. Our findings emphasize the critical importance of molecular surveillance of S. brasiliensis for outbreak response. A comprehensive one-health strategy is mandatory to control the spread of cat-transmitted sporotrichosis driven by S. brasiliensis, encompassing sanitary barriers, quick diagnosis, and treatment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esporotricosis / Sporothrix / Enfermedades de los Gatos Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mycopathologia Año: 2024 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esporotricosis / Sporothrix / Enfermedades de los Gatos Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Mycopathologia Año: 2024 Tipo del documento: Article País de afiliación: Brasil