Blood Micro-sampling: An alternative blood collection method for radioiodine therapy dosimetry.
Phys Med
; 124: 103430, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39047405
ABSTRACT
PURPOSE:
Collecting venous blood samples from patients post administration of high therapeutic activities results in radiation exposure to staff collecting the blood. This study investigated the use of finger-tip capillary-blood collection as an alternative to the venous-blood collection method recommended by the European Association of Nuclear Medicine (EANM) dosimetry protocol for quantifying 131I concentration in the critical organ after therapeutic dose of 131I.METHODS:
The study included differentiated thyroid cancer patients referred to a thyroid cancer centre at St James's Hospital, Ireland, for therapeutic and diagnostic oral administration of 131I. The 15 patients recruited for this study provided 30 venous and capillary paired-blood samples. The activity concentration of the blood samples was compared between the type of blood (venous vs capillary) and the geometry/volume of the blood (1.0 ml versus 0.03 ml). Other variables were also investigated including administered activities, dose to staff performing the sampling, duration of sampling and time since administration.RESULTS:
Blood samples were taken at 2.0-91.9 h post administration using 0.2 ± 0.0 GBq (n = 2) or 4.0 ± 0.1 GBq (n = 28) 131I activities. There was no significant difference found between different blood sampling types (-1.0 ± 4.3 %, p = 0.223), different blood volumes (-3.2 ± 10.0 %, p = 0.070), or between their combination. No significant correlation was found between the percentage differences and investigated parameters.CONCLUSION:
A high degree of accuracy was achieved with blood radioactivity quantified using capillary blood collection using the finger-prick method. Further validation of the method would be required prior to implementation, to investigate patient specific factors which may affect accuracy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Radiometría
/
Recolección de Muestras de Sangre
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Radioisótopos de Yodo
Límite:
Female
/
Humans
Idioma:
En
Revista:
Phys Med
Asunto de la revista:
BIOFISICA
/
BIOLOGIA
/
MEDICINA
Año:
2024
Tipo del documento:
Article