Assessing Leg Blood Flow and Cardiac Output During Running Using Thermodilution.
Scand J Med Sci Sports
; 34(8): e14705, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39056564
ABSTRACT
Cardiac output (QÌC) and leg blood flow (QÌLEG) can be measured simultaneously with high accuracy using transpulmonary and femoral vein thermodilution with a single-bolus injection. The invasive measure has offered important insight into leg hemodynamics and blood flow distribution during exercise. Despite being the natural modality of exercise in humans, there has been no direct measure of QÌLEG while running in humans. We sought to determine the feasibility of the thermodilution technique for measuring QÌLEG and conductance during high-intensity running, in an exploratory case study. A trained runner (30 years male) completed two maximal incremental tests on a cycle ergometer and motorized treadmill. QÌLEG and QÌC were determined using the single-bolus thermodilution technique. Arterial and venous blood were sampled throughout exercise, with continuous monitoring of metabolism, intra-arterial and venous pressure, and temperature. The participant reached a greater peak oxygen uptake (VÌO2peak) during running relative to cycling (74 vs. 68 mL/kg/min) with comparable QÌLEG (19.0 vs. 19.5 L/min) and QÌC (27.4 vs. 26.2 L/min). Leg vascular conductance was greater during high-intensity running relative to cycling (82 vs. 70 mL/min/mmHg @ ~80% VÌO2peak). The "beat phenomenon" was apparent in femoral flow while running, producing large gradients in conductance (62-90 mL/min/mmHg @ 70% VÌO2peak). In summary, we present the first direct measure of QÌLEG and conductance in a running human. Our findings corroborate several assumptions about QÌLEG during running compared with cycling. Importantly, we demonstrate that using thermodilution in running exercise can be completed effectively and safely.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
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Flujo Sanguíneo Regional
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Carrera
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Termodilución
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Gasto Cardíaco
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Pierna
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Scand J Med Sci Sports
Asunto de la revista:
MEDICINA ESPORTIVA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá