Genus Carissa L.: a newly explored sustainable source of virulence inhibitors: a mini review.
Nat Prod Res
; : 1-18, 2024 Jul 31.
Article
en En
| MEDLINE
| ID: mdl-39082374
ABSTRACT
Misuse of antibiotics led to the world wide spread of antimicrobial resistance threatening human lives. The notable resistance of bacterial cells to antibiotics and immune system is the difficulty associated with biofilm-linked illnesses. Natural products from plant origin with antibiofilm activity could provide more therapeutic activity with fewer adverse effects. Carissa L. is a potential drug candidate that can be considered as an agro-food waste sustainable virulence inhibitor source. This mini-review sheds light on recent studies dealing with the anti-virulence potential of Carissa species and its different mechanisms of action. The traced articles revealed that Carissa species exhibited potent antibiofilm, anti-quorum sensing, hyaluronidase inhibitory and anti-adhesion potentials, in addition to violacein, and swimming motility inhibition activities. Ursolic acid, oleanolic acid, and methyl oleanate are the main phytoconstituents of Carissa with claimed virulence inhibitory potentials. Carissa species are safe, valuable, and effective anti-virulence drugs suppressing pathogenicity when compared to conventional antibiotics.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Nat Prod Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
Egipto