Examining breast cancer screening recommendations in Canada: The projected resource impact of screening among women aged 40-49.
J Med Screen
; : 9691413241267845, 2024 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-39106352
ABSTRACT
OBJECTIVE:
To quantify the resource use of revising breast cancer screening guidelines to include average-risk women aged 40-49 years across Canada from 2024 to 2043 using a validated microsimulation model.SETTING:
OncoSim-Breast microsimulation platform was used to simulate the entire Canadian population in 2015-2051.METHODS:
We compared resource use between current screening guidelines (biennial screening ages 50-74) and alternate screening scenarios, which included annual and biennial screening for ages 40-49 and ages 45-49, followed by biennial screening ages 50-74. We estimated absolute and relative differences in number of screens, abnormal screening recalls without cancer, total and negative biopsies, screen-detected cancers, stage of diagnosis, and breast cancer deaths averted.RESULTS:
Compared with current guidelines in Canada, the most intensive screening scenario (annual screening ages 40-49) would result in 13.3% increases in the number of screens and abnormal screening recalls without cancer whereas the least intensive scenario (biennial screening ages 45-49) would result in a 3.4% increase in number of screens and 3.8% increase in number of abnormal screening recalls without cancer. More intensive screening would be associated with fewer stage II, III, and IV diagnoses, and more breast cancer deaths averted.CONCLUSIONS:
Revising breast cancer screening in Canada to include average-risk women aged 40-49 would detect cancers earlier leading to fewer breast cancer deaths. To realize this potential clinical benefit, a considerable increase in screening resources would be required in terms of number of screens and screen follow-ups. Further economic analyses are required to fully understand cost and budget implications.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Med Screen
Asunto de la revista:
EPIDEMIOLOGIA
/
SAUDE PUBLICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá