Medial prefrontal cortex circuitry and social behaviour in autism.
Neuropharmacology
; 260: 110101, 2024 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-39128583
ABSTRACT
Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its underlying genetic causes and the huge variability in symptom presentation. Uncovering common phenotypes across people with ASD and pre-clinical models allows us to better understand the influence on brain function of the many different genetic and cellular processes thought to contribute to ASD aetiology. One such feature of ASD is the convergent evidence implicating abnormal functioning of the medial prefrontal cortex (mPFC) across studies. The mPFC is a key part of the 'social brain' and may contribute to many of the changes in social behaviour observed in people with ASD. Here we review recent evidence for mPFC involvement in both ASD and social behaviours. We also highlight how pre-clinical mouse models can be used to uncover important cellular and circuit-level mechanisms that may underly atypical social behaviours in ASD. This article is part of the Special Issue on "PFC circuit function in psychiatric disease and relevant models".
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conducta Social
/
Corteza Prefrontal
/
Trastorno del Espectro Autista
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropharmacology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido