[Correlation of anti-C1q antibodies with active systemic lupus erythematosus and lupus nephritis in children]. / æC1qæä½ä¸å¿ç«¥æ´»å¨æ§ç³»ç»æ§çº¢æç¼ç®åæ´»å¨æ§ç¼ç®æ§è¾ççç¸å
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Zhongguo Dang Dai Er Ke Za Zhi
; 26(8): 835-839, 2024 Aug 15.
Article
en Zh
| MEDLINE
| ID: mdl-39148388
ABSTRACT
OBJECTIVES:
To study the correlation of anti-C1q antibodies with active systemic lupus erythematosus (SLE) and lupus nephritis (LN) in children, as well as their diagnostic value for active SLE and LN.METHODS:
A retrospective selection of 90 hospitalized children with SLE at the Children's Medical Center of Second Xiangya Hospital, Central South University from January 2016 to March 2019 as the SLE group, all of whom were tested for anti-C1q antibodies. A control group was formed by collecting 70 hospitalized children with other autoimmune diseases (OAD) during the same period. The differences in anti-C1q antibody levels were compared between two groups.The correlation of anti-C1q antibodies with various indicators of SLE and LN was analyzed, and the diagnostic value of anti-C1q in SLE and LN was evaluated.RESULTS:
The serum levels of anti-C1q antibodies in the SLE group were higher than those in the OAD group (P<0.05). The SLE disease activity index score was positively correlated with anti-C1q antibodies (rs=0.371, P<0.001) and positively correlated with anti-double-stranded DNA antibodies (rs=0.370, P<0.001). The sensitivity and specificity of anti-C1q antibodies for diagnosing active SLE were 89.90% and 53.90%, respectively, with an area under the curve of 0.720 (P<0.05) and a critical value of 5.45 U/mL. The sensitivity and specificity of anti-C1q antibody levels for diagnosing active LN were 58.50% and 85.00%, respectively, with an area under the curve of 0.675 (P<0.05) and a critical value of 22.05 U/mL.CONCLUSIONS:
Anti-C1q antibodies can serve as non-invasive biomarkers for evaluating the activity of SLE or predicting the activity of LN in children.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Nefritis Lúpica
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Complemento C1q
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Lupus Eritematoso Sistémico
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2024
Tipo del documento:
Article
País de afiliación:
China