Experimental leprosy in three species of monkeys.
Science
; 227(4686): 529-31, 1985 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-3917577
ABSTRACT
Eleven mangabey monkeys inoculated with Mycobacterium leprae developed lepromatous-type leprosy. Nine of the mangabeys were inoculated with M. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with human M. leprae passaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derived M. leprae also developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Haplorrinos
/
Modelos Animales de Enfermedad
/
Lepra
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1985
Tipo del documento:
Article