Loss of tolerance to dietary proteins: From mouse models to human model diseases.
Immunol Rev
; 326(1): 173-190, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39295093
ABSTRACT
The critical importance of the immunoregulatory mechanisms, which prevent adverse responses to dietary proteins is demonstrated by the consequences of their failure in two common but distinct human pathological conditions, food allergy and celiac disease. The mechanisms of tolerance to dietary proteins have been extensively studied in mouse models but the extent to which the results in mice can be extrapolated to humans remains unclear. Here, after summarizing the mechanisms known to control oral tolerance in mouse models, we discuss how the monogenic immune disorders associated with food allergy on the one hand, and celiac disease, on the other hand, represent model diseases to gain insight into the key immunoregulatory pathways that control immune responses to food antigens in humans. The spectrum of monogenic disorders, in which the dysfunction of a single gene, is strongly associated with TH2-mediated food allergy suggests an important overlap between the mechanisms that regulate TH2 and IgE responses to food antigens in humans and mice. In contrast, celiac disease provides a unique example of the link between autoimmunity and loss of tolerance to a food antigen.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas en la Dieta
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Enfermedad Celíaca
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Modelos Animales de Enfermedad
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Hipersensibilidad a los Alimentos
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Tolerancia Inmunológica
Límite:
Animals
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Humans
Idioma:
En
Revista:
Immunol Rev
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia