A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency.
Science
; 385(6716): eadk2536, 2024 Sep 27.
Article
en En
| MEDLINE
| ID: mdl-39325906
ABSTRACT
Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as Tomasiella immunophila, that induces and degrades IgA in the mouse intestine. Mice harboring T. immunophila are susceptible to infections and show poor mucosal repair. T. immunophila is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid. It delivers immunoglobulin-degrading proteases into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. This work indicates a role for symbionts in immunodeficiency, which might be applicable to human disease.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bacterias
/
Inmunoglobulina A
/
Microbioma Gastrointestinal
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Interacciones Microbiota-Huesped
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Síndromes de Inmunodeficiencia
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Mucosa Intestinal
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos