Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.
Science
; 182(4108): 171-3, 1973 Oct 12.
Article
en En
| MEDLINE
| ID: mdl-4581053
ABSTRACT
Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas glucagon in the controls rose significantly. Thus in diabetics pancreatic alpha cells are insensitive to glucose even in the presence of large amounts of circulating insulin. An intrinsic defect common to both alpha and beta pancreatic cells-failure to recognize (or respond to) plasma glucose fluctuations-may be operative in juvenile diabetes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glucagón
/
Islotes Pancreáticos
/
Diabetes Mellitus Tipo 1
/
Hipoglucemia
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Science
Año:
1973
Tipo del documento:
Article