Human serum contains a lectin which inhibits hepatic uptake of glycoproteins.
FEBS Lett
; 173(1): 63-6, 1984 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-6086401
ABSTRACT
Human serum will inhibit the specific uptake of N-acetylglucosamine-terminated glycoproteins by isolated rat hepatic sinusoidal cells. The serum inhibitors are not glycoproteins that bind to the hepatic mannose/N-acetylglucosamine receptor but have the properties of lectins which bind to mannose/N-acetylglucosamine-terminated glycoproteins. They can be isolated from serum by affinity chromatography. The predominant lectin, with a molecular mass of less than 35 kDa, will inhibit the sinusoidal cell uptake of glycoproteins in vitro.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asialoglicoproteínas
/
Glicoproteínas
/
Receptores Inmunológicos
/
Lectinas de Unión a Manosa
/
Lectinas
/
Hígado
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
FEBS Lett
Año:
1984
Tipo del documento:
Article