Fab2 fragments from HLA xenoantisera specifically block cytolysis mediated by HLA-AB alloantisera.
J Immunogenet
; 7(3): 215-9, 1980 Jun.
Article
en En
| MEDLINE
| ID: mdl-6157749
ABSTRACT
Fab2 fragments from antisera raised in rabbits with partially purified cellular and serum HLA antigens were tested for their ability to block the cytolytic activity of operationally specific HLA-A,B alloantisera. One Fab2 fragment preparation blocked the cytolytic activity of all the HLA-A,B alloantisera tested; the remaining nine inhibited the lytic activity of alloantisera to certain HLA-A,B allospecificities, suggesting that these xenoantisera contain antibody to certain HLA-A,B allotype determinants or to closely associated structures. In contrast to previous reports in the literature none of the xenoantisera contained significant amounts of antibodies to human beta 2-microglobulin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conejos
/
Fragmentos Fab de Inmunoglobulinas
/
Antígenos HLA
/
Alotipos de Inmunoglobulinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunogenet
Año:
1980
Tipo del documento:
Article